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Staurosporine inhibits cell proliferation and in vivo protein phosphorylation induced by phorbolester.
2
The C2 domain-swapped mutants were inactive in phorbolester-induced membrane translocation.
3
Such an effect was not seen with inactive phorbolester.
4
In contrast, basal and phorbolester-stimulated PLD activities were not or only slightly reduced.
5
In the presence of cholesterol sulfate, phorbolester only weakly enhanced the activity of nPKC eta.
Usage of phorbol esters in inglés
1
Neither agonists acting through seven-membrane-spanning receptors nor phorbolesters stimulate MAP kinase in hepatocytes.
2
Activation of protein kinase C by phorbolesters inhibits the endothelium-dependent relaxations evoked by certain stimuli.
3
These data show that phorbolesters can exert either positive or negative synergisms depending on the experimental conditions.
4
Thus, stimulation of monocyte cell lines by phorbolesters or TNF alpha induces cell differentiation and activates HIV transcription.
5
The increases in protein kinase C levels were accompanied by increases in activation of the enzyme by phorbolesters.
6
The expression of the intrinsic H-related antigen on MEG-01 cells decreased concomitant to megakaryocytic differentiation induced by phorbolesters.
7
Docosahexaenoic acid action was associated with marked GPR120 internalization whereas that induced with phorbolesters was smaller at early times.
8
Cell culture studies with TPA and other phorbolesters provide clues to tumor promotion and the multistep nature of carcinogenesis.
9
In cultured human pancreatic cancer cells, levels of COX-2 mRNA and protein were induced by treatment with tumor-promoting phorbolesters.
10
Based on the resultant structure, we propose an interaction site of the cysteine-rich domain of protein kinase C with diacylglycerols and phorbolesters.
11
Human monocyte-derived DC were found to express the NADPH oxidase components and to release superoxide anions in response to phorbolesters and phagocytic agonists.
12
Furthermore, CD9 antigen expression increased while culturing these cells with phorbolesters, and was also found in the cytoplasm by means of indirect immunofluorescence test.
13
The promoter was stimulated 8-20-fold by phorbolesters accounting for the previously observed transcriptional activation of protein kinase C beta.
14
It has been shown that receptor agonists and activators of protein kinase C, phorbolesters, increase Ca2+ sensitivity of contractile elements in vascular smooth muscle.
15
Antigen receptor signals could be mimicked by suboptimal activation of protein kinase C (PKC) with phorbolesters in combination with calcium mobilization by an ionophore.
16
Activation of HO2 by phorbolesters, that stimulate protein kinase C to phosphorylate HO2, augments production of bilirubin which protects brain cultures from oxidative stress.